UGT2B27P

Across TCGA patient cohorts, UGT2B27P mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT2B27P-associated genes across cancer lineages are PRAS40_pT246, TIGAR, and eEF2. Each is linked with UGT2B27P in more than 2 cancer types. Because this analysis shows association rather than direction, both UGT2B27P-to-partner and partner-to-UGT2B27P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by UGT2B27P-low versus UGT2B27P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2B27P→partner) and Y-score (partner→UGT2B27P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.192	+1.678	.001	.021	3	3
UCEC	TIGAR →	+0.177	+2.096	<.001	.001	3	2
UCEC	eEF2 →	+0.296	+2.321	.016	.033	3	1
UCEC	eIF4E →	+0.197	+2.070	.007	.001	3	1
UCEC	ERK2 →	+0.192	+1.736	.003	.007	3	1
UCEC	Lck →	+0.152	+2.000	.028	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PRAS40_pT246 by UGT2B27P expression — UCEC

Explore this box plot interactively →