UGT2A3

Across TCGA cell cohorts, UGT2A3 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UGT2A3-associated genes across cancer lineages are CLEC1B, MS4A13, and OR5M1. Each is linked with UGT2A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT2A3-to-partner and partner-to-UGT2A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC1B grouped by UGT2A3-low versus UGT2A3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2A3→partner) and Y-score (partner→UGT2A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CLEC1B →	+0.048	+5.029	<.001	.006	3	1
LUNG_SCLC	MS4A13 →	+0.046	+5.643	<.001	.002	3	1
LUNG_SCLC	OR5M1 →	+0.022	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR4D5 →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	POTEB →	+0.012	+5.813	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR10G2 →	+0.026	+4.212	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

CLEC1B by UGT2A3 expression — LUNG_SCLC

Explore this box plot interactively →