UGT2A3

Across TCGA pan-cancer cohorts, UGT2A3 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of UGT2A3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where UGT2A3 RNA is repressed in tumor relative to normal tissue. In most cancer types UGT2A3 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and KIRC are the cancer types where UGT2A3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UGT2A3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−4.917	<.001	12	view →
KICH	All	IV	−5.922	<.001	11	view →
KIRC	Male	II,III,IV	+1.758	<.001	9	view →
READ	All	All	−4.033	<.001	5	view →
CHOL	All	II,III,IV	−3.030	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

UGT2A3–COAD

Open the COAD breakdown →