UGGT2

Across TCGA patient cohorts, UGGT2 mutation is significantly associated with the RNA expression of many other genes, with 4,049 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGGT2-associated genes across cancer lineages are OR2Q1P, PHF5A, and OIP5. Each is linked with UGGT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both UGGT2-to-partner and partner-to-UGGT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2Q1P grouped by UGGT2-low versus UGGT2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGGT2→partner) and Y-score (partner→UGGT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR2Q1P →	+0.096	+3.885	<.001	<.001	3	3
COAD	PHF5A →	+0.460	+3.625	<.001	.001	3	3
UCEC	OIP5 →	+0.689	+2.343	<.001	<.001	3	3
UCEC	ATP5F1B →	+0.464	+1.660	.001	.003	3	3
UCEC	RFC5 →	+0.414	+1.660	.001	.003	3	3
COAD	MED9 →	+0.386	+3.827	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,049 associations by consensus.

OR2Q1P by UGGT2 expression — BRCA

Explore this box plot interactively →