UGDH

Across TCGA patient cohorts, UGDH mutation is significantly associated with the RNA expression of many other genes, with 2,337 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGDH-associated genes across cancer lineages are BNIP3P41, RN7SL248P, and RNU6-637P. Each is linked with UGDH in more than 1 cancer types. Because this analysis shows association rather than direction, both UGDH-to-partner and partner-to-UGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP3P41 grouped by UGDH-low versus UGDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGDH→partner) and Y-score (partner→UGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BNIP3P41 →	+0.013	+4.390	<.001	.003	3	2
UCEC	RN7SL248P →	+0.073	+3.307	<.001	.003	3	2
BLCA	RNU6-637P →	+0.460	+8.051	<.001	<.001	3	2
LUSC	RNA5SP34 →	+0.261	+7.924	<.001	.008	3	2
BLCA	GTF3AP6 →	+0.036	+5.899	.008	.002	3	2
BLCA	OR11I1P →	+0.040	+6.018	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,337 associations by consensus.

BNIP3P41 by UGDH expression — UCEC

Explore this box plot interactively →