UGDH

Across TCGA pan-cancer cohorts, UGDH RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of UGDH’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where UGDH RNA is repressed in tumor relative to normal tissue. In most cancer types UGDH is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, LUAD, and KICH are the cancer types where UGDH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UGDH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.924	<.001	11	view →
LUAD	Male	II,III,IV	+1.779	<.001	11	view →
KICH	Female	II,III,IV	−1.892	<.001	9	view →
HNSC	All	II,III,IV	+0.878	<.001	9	view →
BRCA	All	All	+0.723	<.001	8	view →
THCA	All	All	−0.380	.001	7	view →
LUSC	Female	All	+1.200	<.001	6	view →
LIHC	Male	All	+1.077	<.001	6	view →
READ	All	All	−1.898	<.001	5	view →
STAD	All	II,III,IV	+0.532	.002	5	view →
KIRP	All	II,III,IV	+0.960	.006	4	view →
UCEC	All	All	+0.653	.019	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

UGDH–COAD

Open the COAD breakdown →