UCP1

Across TCGA patient cohorts, UCP1 protein abundance is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible UCP1-associated genes across cancer lineages are NIN, CHMP3, and RN7SKP69. Each is linked with UCP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UCP1-to-partner and partner-to-UCP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, UCP1 versus NIN in BRCA, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UCP1→partner) and Y-score (partner→UCP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NIN →	+0.537	+2.211	.008	.005	3	1
BRCA	CHMP3 →	+0.664	+1.812	.003	.007	3	1
BRCA	RN7SKP69 →	+0.495	+1.482	.001	.009	3	1
BRCA	RNA5SP390 →	+1.132	+2.027	<.001	<.001	3	1
BRCA	KCND3-AS1 →	+0.317	+1.814	.003	.002	3	1
BRCA	MIR3157 →	+1.096	+1.703	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

UCP1 vs NIN — BRCA

Explore this scatter interactively →