UCP1

Across TCGA pan-cancer cohorts, UCP1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of UCP1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where UCP1 RNA is repressed in tumor relative to normal tissue. In most cancer types UCP1 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, COAD, and LUAD are the cancer types where UCP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UCP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.118	<.001	8	view →
COAD	All	All	+0.056	<.001	7	view →
LUAD	Female	II,III,IV	−0.176	<.001	6	view →
BRCA	Female	II,III,IV	−0.611	<.001	4	view →
KIRC	Male	III,IV	−0.058	<.001	4	view →
CHOL	All	All	+0.132	.003	3	view →
LUSC	Male	All	+0.215	.036	2	view →
HNSC	All	All	+0.113	.038	2	view →
LIHC	All	All	+0.021	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

UCP1–THCA

Open the THCA breakdown →