UCP1

Across TCGA pan-cancer cohorts, UCP1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated UCP1 data layer compared with 6 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher UCP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UCP1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and THYM show a favorable association.

SKCM, LUSC, and LGG are the cancer types where UCP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	III,IV	0.479	0.698	<.001	60	view →
LUSC	OS	Tertile	II,III,IV	0.728	0.543	.003	45	view →
LGG	DFS	Median	All	0.676	0.796	<.001	37	view →
THYM	DFS	Median	All	0.971	0.832	.002	37	view →
PCPG	OS	Quartile	All	0.665	1.000	.001	22	view →
THCA	DFS	Quartile	II,III,IV	0.804	0.994	<.001	19	view →
ESCA	DFS	Tertile	IV	0.331	0.785	.024	18	view →
UCEC	DFS	Tertile	IV	0.881	0.498	.014	16	view →
BRCA	OS	Quartile	III,IV	0.932	0.815	.014	14	view →
SCLC	OS	Quartile	All	0.837	0.626	.023	8	view →
LIHC	OS	Tertile	All	0.701	0.800	.037	8	view →
HNSC	DFS	Tertile	II,III,IV	0.756	0.640	.014	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

UCP1–SKCM (DFS)

Open the SKCM breakdown →