UCP1

Across TCGA patient cohorts, UCP1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UCP1-associated genes across cancer lineages are 14-3-3_beta, Myosin-IIa, and Paxillin. Each is linked with UCP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UCP1-to-partner and partner-to-UCP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by UCP1-low versus UCP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UCP1→partner) and Y-score (partner→UCP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.134	-2.986	.020	.037	3	1
UCEC	Myosin-IIa →	+0.264	+2.814	.020	.036	3	1
UCEC	Paxillin →	+0.297	+2.817	.047	.036	3	1
UCEC	Shc_pY317 →	-0.222	-3.000	.011	.037	2	2
UCEC	Syk →	+0.436	+3.013	.044	.019	3	1
UCEC	P-Cadherin →	-0.182	-2.986	.029	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

14-3-3_beta by UCP1 expression — UCEC

Explore this box plot interactively →