UCMA

Across TCGA patient cohorts, UCMA mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UCMA-associated genes across cancer lineages are 4E-BP1, eIF4E, and Heregulin. Each is linked with UCMA in more than 1 cancer types. Because this analysis shows association rather than direction, both UCMA-to-partner and partner-to-UCMA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by UCMA-low versus UCMA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UCMA→partner) and Y-score (partner→UCMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.358	+2.199	.004	.033	3	2
UCEC	eIF4E →	+0.226	+2.584	.021	.011	3	1
UCEC	Heregulin →	-0.193	-3.321	<.001	.010	3	1
UCEC	JNK2 →	+0.356	+3.026	<.001	.018	3	1
UCEC	Ku80 →	+0.242	+1.887	.028	.031	3	1
UCEC	MEK1 →	+0.577	+3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

4E-BP1 by UCMA expression — UCEC

Explore this box plot interactively →