UBTF

Across TCGA cell cohorts, UBTF mutation is significantly associated with the RNA expression of many other genes, with 283 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBTF-associated genes across cancer lineages are PCDH11X, OR1E2, and OR3A1. Each is linked with UBTF in more than 1 cancer types. Because this analysis shows association rather than direction, both UBTF-to-partner and partner-to-UBTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDH11X grouped by UBTF-low versus UBTF-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBTF→partner) and Y-score (partner→UBTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PCDH11X →	+0.701	+3.823	<.001	.006	3	1
SKIN	OR1E2 →	+0.046	+4.022	<.001	.006	3	1
SKIN	OR3A1 →	+0.158	+3.510	<.001	.003	3	1
SKIN	OR3A2 →	+0.554	+3.878	<.001	.003	3	1
LARGE_INTESTINE	CBY1 →	+0.836	+3.330	<.001	.002	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.634	+3.364	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 283 associations by consensus.

PCDH11X by UBTF expression — SKIN

Explore this box plot interactively →