UBTF

Across TCGA pan-cancer cohorts, UBTF RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated UBTF data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher UBTF RNA is associated with better overall survival. In most high-consensus cancer types, elevated UBTF expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRC show a favorable association.

BRCA, ACC, and KIRC are the cancer types where UBTF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	III,IV	0.913	0.750	<.001	72	view →
ACC	DFS	Median	II,III,IV	0.198	0.608	<.001	64	view →
KIRC	DFS	Median	All	0.717	0.524	.004	41	view →
LIHC	DFS	Quartile	All	0.408	0.617	<.001	41	view →
THYM	DFS	Median	All	0.898	0.421	.001	30	view →
HNSC	DFS	Tertile	All	0.440	0.289	.002	28	view →
LUSC	DFS	Median	III,IV	0.405	0.884	.006	24	view →
KICH	OS	Quartile	All	0.473	1.000	.005	16	view →
UCEC	OS	Tertile	III,IV	0.879	0.787	.020	12	view →
GBM	DFS	Median	All	0.381	0.194	.004	11	view →
UVM	DFS	Median	II,III,IV	0.340	0.576	.016	8	view →
PAAD	OS	Tertile	All	0.426	0.222	.020	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

UBTF–BRCA (OS)

Open the BRCA breakdown →