UBR3

Across TCGA patient cohorts, UBR3 mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBR3-associated genes across cancer lineages are Caspase-7-cleavedD198, INPP4B, and Ku80. Each is linked with UBR3 in more than 3 cancer types. Because this analysis shows association rather than direction, both UBR3-to-partner and partner-to-UBR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by UBR3-low versus UBR3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBR3→partner) and Y-score (partner→UBR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.130	+2.095	<.001	.003	3	4
COAD	INPP4B →	-0.375	-2.584	.003	.010	3	3
COAD	Ku80 →	-0.223	-2.459	.037	.018	3	3
COAD	Akt →	-0.364	-1.807	.022	.024	3	3
COAD	Rad50 →	-0.164	-2.089	.049	.017	3	3
COAD	RAD51 →	+0.222	+2.593	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

Caspase-7-cleavedD198 by UBR3 expression — COAD

Explore this box plot interactively →