UBR3

Across TCGA pan-cancer cohorts, UBR3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated UBR3 data layer compared with 11 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher UBR3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated UBR3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUSC show a favorable association.

KIRC, UVM, and KIRP are the cancer types where UBR3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.701	0.563	<.001	86	view →
UVM	DFS	Median	III,IV	0.273	0.703	.006	33	view →
KIRP	OS	Median	All	0.900	0.961	.006	18	view →
LUSC	OS	Quartile	II,III,IV	0.822	0.610	.003	16	view →
HNSC	DFS	Tertile	IV	0.436	0.233	.005	15	view →
PRAD	DFS	Quartile	All	0.956	0.873	.012	12	view →
MESO	OS	Quartile	III,IV	0.395	0.647	.014	12	view →
SARC	OS	Quartile	All	0.820	0.597	.011	12	view →
OV	DFS	Median	II,III,IV	0.412	0.347	.032	12	view →
DLBC	DFS	Quartile	All	0.604	1.000	.007	11	view →
STAD	DFS	Tertile	II,III,IV	0.412	0.636	.011	10	view →
BRCA	DFS	Tertile	III,IV	0.915	0.806	.019	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

UBR3–KIRC (OS)

Open the KIRC breakdown →