UBR3

Across TCGA pan-cancer cohorts, UBR3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of UBR3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where UBR3 RNA is repressed in tumor relative to normal tissue. In most cancer types UBR3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and KIRC are the cancer types where UBR3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBR3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.501	<.001	9	view →
KICH	Female	All	−0.857	<.001	6	view →
KIRC	Male	III,IV	−0.410	.003	6	view →
KIRP	Male	All	−0.700	<.001	5	view →
BRCA	Female	All	−0.222	.005	4	view →
PAAD	Male	All	+0.480	.034	2	view →
UCEC	All	All	−0.400	.034	2	view →
LIHC	All	All	+0.302	.007	2	view →
ESCA	Female	All	+0.713	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

UBR3–THCA

Open the THCA breakdown →