UBR3

Across TCGA cell cohorts, UBR3 mutation is significantly associated with the RNA expression of many other genes, with 358 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBR3-associated genes across cancer lineages are SPO11, GAGE12E, and TMEM114. Each is linked with UBR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBR3-to-partner and partner-to-UBR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPO11 grouped by UBR3-low versus UBR3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBR3→partner) and Y-score (partner→UBR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPO11 →	+0.022	+5.969	<.001	.001	3	2
LUNG_NSCLC_LUSC	GAGE12E →	+0.076	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	TMEM114 →	+0.096	+4.643	<.001	.008	3	1
PANCREAS	IL17A →	+0.006	+5.614	<.001	.002	3	1
PANCREAS	SPATA3 →	+0.370	+5.614	<.001	.002	3	1
SOFT_TISSUE	LYZL6 →	+0.019	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 358 associations by consensus.

SPO11 by UBR3 expression — BLOOD_Leukemia

Explore this box plot interactively →