UBQLN3

Across TCGA patient cohorts, UBQLN3 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBQLN3-associated genes across cancer lineages are ATM, MEK1, and FoxM1. Each is linked with UBQLN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both UBQLN3-to-partner and partner-to-UBQLN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by UBQLN3-low versus UBQLN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBQLN3→partner) and Y-score (partner→UBQLN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.609	-2.700	<.001	.006	3	4
UCEC	MEK1 →	+0.348	+2.321	.011	.005	3	3
UCEC	FoxM1 →	+0.220	+1.765	.023	.014	3	3
UCEC	Notch1 →	+0.202	+2.335	<.001	.002	3	3
UCEC	STAT3_pY705 →	-0.344	-1.700	<.001	.040	3	3
UCEC	Cyclin-B1 →	+0.779	+3.321	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ATM by UBQLN3 expression — UCEC

Explore this box plot interactively →