UBL4A

Across TCGA patient cohorts, UBL4A mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBL4A-associated genes across cancer lineages are EGFR_pY1068, JNK2, and Lck. Each is linked with UBL4A in more than 1 cancer types. Because this analysis shows association rather than direction, both UBL4A-to-partner and partner-to-UBL4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by UBL4A-low versus UBL4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBL4A→partner) and Y-score (partner→UBL4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.386	-2.321	.001	.033	3	1
UCEC	JNK2 →	+0.279	+3.009	.003	.019	3	1
UCEC	Lck →	+0.204	+3.000	.035	.036	3	1
UCEC	MEK1 →	+0.439	+3.169	.013	.019	3	1
UCEC	MIG-6 →	+0.107	+2.179	.026	.034	3	1
UCEC	MSH2 →	-0.340	-3.143	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR_pY1068 by UBL4A expression — UCEC

Explore this box plot interactively →