UBL4A

Across TCGA pan-cancer cohorts, UBL4A RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of UBL4A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UBL4A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBL4A is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where UBL4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBL4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.036	<.001	12	view →
KIRC	Female	III,IV	+0.619	<.001	12	view →
COAD	Female	All	+0.943	<.001	11	view →
LIHC	Male	II,III,IV	+1.629	<.001	9	view →
LUAD	Male	All	+0.637	<.001	9	view →
KIRP	All	III,IV	+0.650	<.001	8	view →
THCA	Female	II,III,IV	+0.656	<.001	7	view →
LUSC	All	All	+0.794	<.001	6	view →
BRCA	All	III,IV	+0.524	<.001	6	view →
CHOL	All	All	+2.218	<.001	5	view →
STAD	Male	II,III,IV	+1.004	<.001	5	view →
READ	All	All	+0.484	.007	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

UBL4A–HNSC

Open the HNSC breakdown →