UBL4A

Across TCGA pan-cancer cohorts, UBL4A RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated UBL4A data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher UBL4A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UBL4A expression acts as an unfavorable survival marker, although some lineages such as READ and SKCM show a favorable association.

KICH, UVM, and LGG are the cancer types where UBL4A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Quartile	III,IV	0.189	1.000	.003	90	view →
UVM	DFS	Median	All	0.429	0.736	<.001	82	view →
LGG	OS	Median	All	0.707	0.914	<.001	49	view →
LIHC	OS	Tertile	All	0.575	0.792	<.001	40	view →
PAAD	DFS	Median	All	0.379	0.633	.002	38	view →
LAML	DFS	Median	All	0.414	0.700	.002	36	view →
BLCA	DFS	Quartile	II,III,IV	0.558	0.735	.005	29	view →
BRCA	OS	Median	All	0.515	0.632	.015	23	view →
COAD	DFS	Quartile	All	0.436	0.820	.010	21	view →
READ	DFS	Median	II,III,IV	0.872	0.379	.015	17	view →
KIRP	OS	Median	All	0.894	0.966	.013	15	view →
UCEC	DFS	Median	All	0.803	0.870	.012	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

UBL4A–KICH (OS)

Open the KICH breakdown →