UBE3D

Across TCGA patient cohorts, UBE3D mutation is significantly associated with the RNA expression of many other genes, with 2,512 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE3D-associated genes across cancer lineages are RPS6P20, RN7SL248P, and RNY3. Each is linked with UBE3D in more than 2 cancer types. Because this analysis shows association rather than direction, both UBE3D-to-partner and partner-to-UBE3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS6P20 grouped by UBE3D-low versus UBE3D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE3D→partner) and Y-score (partner→UBE3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS6P20 →	+0.060	+1.747	.009	.004	3	3
UCEC	RN7SL248P →	+0.053	+2.985	<.001	.006	3	2
HNSC	RNY3 →	+0.385	+5.069	<.001	.008	3	2
HNSC	RNU6-258P →	+0.396	+6.339	<.001	.001	3	2
LUAD	RN7SKP65 →	+0.157	+4.554	<.001	.001	3	2
UCEC	SNX9 →	+0.425	+1.858	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,512 associations by consensus.

RPS6P20 by UBE3D expression — UCEC

Explore this box plot interactively →