UBE3D

Across TCGA pan-cancer cohorts, UBE3D RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated UBE3D data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher UBE3D RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UBE3D expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

LIHC, KIRC, and READ are the cancer types where UBE3D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Tertile	All	0.417	0.646	<.001	107	view →
KIRC	DFS	Quartile	All	0.905	0.818	.001	60	view →
READ	OS	Tertile	All	0.840	0.487	.001	43	view →
SKCM	OS	Median	IV	0.867	0.236	.003	24	view →
KICH	DFS	Tertile	III,IV	0.343	1.000	.010	22	view →
GBM	DFS	Quartile	All	0.477	0.157	<.001	22	view →
MESO	OS	Tertile	All	0.322	0.558	.015	21	view →
KIRP	OS	Median	All	0.833	0.961	.001	20	view →
ACC	OS	Quartile	III,IV	0.818	0.306	.001	17	view →
LGG	DFS	Quartile	All	0.481	0.297	.011	16	view →
UCEC	DFS	Tertile	All	0.811	0.882	.023	16	view →
SARC	OS	Tertile	All	0.644	0.834	.001	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

UBE3D–LIHC (DFS)

Open the LIHC breakdown →