UBE2V2

Across TCGA patient cohorts, UBE2V2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2V2-associated genes across cancer lineages are EGFR_pY1068, ER-alpha_pS118, and ERK2. Each is linked with UBE2V2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2V2-to-partner and partner-to-UBE2V2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by UBE2V2-low versus UBE2V2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2V2→partner) and Y-score (partner→UBE2V2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.290	-3.700	.013	.001	3	1
UCEC	ER-alpha_pS118 →	-0.404	-2.584	.015	.011	3	1
UCEC	ERK2 →	+0.269	+2.321	.002	.034	3	1
UCEC	GAPDH →	+0.613	+2.999	.014	.035	3	1
UCEC	GATA6 →	-0.150	-3.000	.037	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.177	-2.571	.024	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by UBE2V2 expression — UCEC

Explore this box plot interactively →