UBE2V2

Across TCGA pan-cancer cohorts, UBE2V2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of UBE2V2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UBE2V2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBE2V2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and KIRC are the cancer types where UBE2V2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBE2V2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.028	<.001	12	view →
THCA	Male	III,IV	−0.540	<.001	10	view →
KIRC	All	All	+0.211	.002	8	view →
LIHC	Male	II,III,IV	+1.044	<.001	7	view →
LUSC	Female	All	+0.792	<.001	6	view →
LUAD	Male	II,III,IV	+0.608	<.001	6	view →
BRCA	All	II,III,IV	+0.519	<.001	6	view →
KICH	Female	All	−0.941	<.001	5	view →
READ	All	III,IV	+0.950	.009	2	view →
CHOL	All	All	+0.881	<.001	2	view →
ESCA	All	All	+0.535	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

UBE2V2–HNSC

Open the HNSC breakdown →