UBE2V2

Across TCGA pan-cancer cohorts, UBE2V2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated UBE2V2 data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher UBE2V2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UBE2V2 expression acts as an unfavorable survival marker, although some lineages such as THYM and LUSC show a favorable association.

UVM, HNSC, and KIRP are the cancer types where UBE2V2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.288	0.776	<.001	120	view →
HNSC	DFS	Tertile	III,IV	0.458	0.643	<.001	106	view →
KIRP	DFS	Median	All	0.863	0.952	<.001	103	view →
KICH	DFS	Tertile	II,III,IV	0.445	0.954	.001	85	view →
ACC	DFS	Tertile	All	0.409	0.829	<.001	70	view →
LIHC	OS	Tertile	All	0.562	0.813	<.001	63	view →
LUAD	OS	Median	All	0.225	0.451	<.001	55	view →
MESO	OS	Quartile	All	0.364	0.621	.003	47	view →
SCLC	DFS	Quartile	All	0.446	0.814	<.001	34	view →
CESC	OS	Quartile	IV	0.241	0.779	.009	30	view →
THYM	OS	Tertile	II,III,IV	1.000	0.640	.007	19	view →
UCEC	DFS	Tertile	All	0.795	0.886	.007	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

UBE2V2–UVM (DFS)

Open the UVM breakdown →