UBE2S

Across TCGA patient cohorts, UBE2S mutation is significantly associated with the RNA expression of many other genes, with 101 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible UBE2S-associated genes across cancer lineages are ASS1P8, LGALS13, and SMR3A. Each is linked with UBE2S in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2S-to-partner and partner-to-UBE2S results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASS1P8 grouped by UBE2S-low versus UBE2S-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2S→partner) and Y-score (partner→UBE2S) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ASS1P8 →	+0.065	+5.624	<.001	.002	3	2
BLCA	LGALS13 →	+0.418	+5.788	<.001	.003	3	1
BLCA	SMR3A →	+0.222	+5.497	<.001	.004	3	1
BLCA	OR10G3 →	+0.056	+5.788	<.001	.003	3	1
BLCA	DEFB123 →	+0.405	+5.106	<.001	.008	3	1
BLCA	RNA5SP307 →	+0.527	+6.444	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

ASS1P8 by UBE2S expression — SKCM

Explore this box plot interactively →