UBE2S

Across TCGA pan-cancer cohorts, UBE2S RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of UBE2S’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UBE2S RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBE2S is over-expressed in tumor.

HNSC, COAD, and LUAD are the cancer types where UBE2S tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBE2S RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+2.282	<.001	12	view →
COAD	Female	II,III,IV	+2.237	<.001	12	view →
LUAD	Male	III,IV	+2.236	<.001	11	view →
BLCA	Male	All	+1.634	<.001	11	view →
KIRP	All	III,IV	+1.162	<.001	11	view →
LIHC	Female	II,III,IV	+2.157	<.001	9	view →
STAD	All	II,III,IV	+1.930	<.001	9	view →
KIRC	Male	All	+0.489	<.001	9	view →
LUSC	Female	II,III,IV	+2.989	<.001	8	view →
UCEC	All	III,IV	+2.147	<.001	8	view →
READ	All	All	+1.683	<.001	7	view →
BRCA	All	III,IV	+1.872	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

UBE2S–HNSC

Open the HNSC breakdown →