UBE2S

Across TCGA pan-cancer cohorts, UBE2S RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated UBE2S data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher UBE2S RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UBE2S expression acts as an unfavorable survival marker, although some lineages such as THYM and GBM show a favorable association.

ACC, KIRP, and KIRC are the cancer types where UBE2S RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.164	0.733	<.001	159	view →
KIRP	DFS	Tertile	All	0.321	0.694	<.001	142	view →
KIRC	DFS	Median	All	0.541	0.716	<.001	138	view →
MESO	OS	Median	All	0.412	0.668	<.001	126	view →
KICH	OS	Median	III,IV	0.524	1.000	<.001	98	view →
UVM	DFS	Median	All	0.423	0.744	<.001	96	view →
LUAD	OS	Median	All	0.759	0.863	<.001	88	view →
LIHC	OS	Median	All	0.592	0.777	<.001	83	view →
LGG	DFS	Median	All	0.654	0.821	<.001	51	view →
UCEC	DFS	Quartile	All	0.846	0.960	<.001	30	view →
SARC	DFS	Quartile	All	0.495	0.689	.002	27	view →
LUSC	OS	Median	III,IV	0.356	0.655	<.001	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

UBE2S–ACC (DFS)

Open the ACC breakdown →