UBE2S

Across TCGA cell cohorts, UBE2S RNA expression is significantly associated with the go_rna of many other GO terms, with 4,389 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UBE2S-associated GO terms across cancer lineages are Positive regulation of ubiquitin protein ligase activity, Establishment of spindle orientation, and Centrosome duplication. Each is linked with UBE2S in more than 17 cancer types. Because this analysis shows association rather than direction, both UBE2S-to-partner and partner-to-UBE2S results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of ubiquitin protein ligase activity grouped by UBE2S-low versus UBE2S-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2S→partner) and Y-score (partner→UBE2S) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of ubiquitin protein ligase activity →	+0.170	+1.814	<.001	.001	3	18
LUNG_SCLC	Establishment of spindle orientation →	+0.095	+0.687	<.001	.002	3	18
OESOPHAGUS	Centrosome duplication →	+0.092	+1.040	.002	.003	3	18
OESOPHAGUS	Chromosome segregation →	+0.113	+1.063	.001	.005	3	18
OESOPHAGUS	Mitotic nuclear division →	+0.106	+1.086	.002	.003	3	17
PANCREAS	Positive regulation of cell cycle →	+0.074	+1.060	<.001	.002	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,389 associations by consensus.

Positive regulation of ubiquitin protein ligase activity by UBE2S expression — BONE

Explore this box plot interactively →