UBE2O

Across TCGA cell cohorts, UBE2O RNA expression is significantly associated with the go_rna of many other GO terms, with 5,523 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UBE2O-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with UBE2O in more than 19 cancer types. Because this analysis shows association rather than direction, both UBE2O-to-partner and partner-to-UBE2O results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by UBE2O-low versus UBE2O-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2O→partner) and Y-score (partner→UBE2O) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Epigenetic regulation of gene expression →	+0.086	+1.148	<.001	<.001	3	20
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.158	+0.755	<.001	<.001	3	17
OESOPHAGUS	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.163	+1.025	.003	<.001	3	17
OESOPHAGUS	Regulation of mRNA catabolic process →	+0.071	+0.725	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.093	+1.103	<.001	<.001	3	17
SOFT_TISSUE	Heterochromatin organization →	+0.070	+0.919	<.001	.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,523 associations by consensus.

Epigenetic regulation of gene expression by UBE2O expression — BONE

Explore this box plot interactively →