UBE2O

Across TCGA pan-cancer cohorts, UBE2O RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of UBE2O’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UBE2O RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBE2O is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and KIRP are the cancer types where UBE2O tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBE2O RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.900	<.001	12	view →
COAD	Female	II,III,IV	+1.001	<.001	11	view →
KIRP	All	II,III,IV	+0.816	<.001	11	view →
KIRC	Female	All	+0.536	<.001	11	view →
BLCA	Female	All	+0.962	<.001	10	view →
THCA	Male	III,IV	−0.835	<.001	10	view →
LIHC	Male	II,III,IV	+1.362	<.001	9	view →
LUAD	All	III,IV	+0.898	<.001	9	view →
LUSC	Male	II,III,IV	+1.297	<.001	8	view →
STAD	Male	II,III,IV	+1.123	<.001	8	view →
BRCA	All	III,IV	+0.576	<.001	6	view →
CHOL	Male	All	+1.871	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

UBE2O–HNSC

Open the HNSC breakdown →