UBE2O

Across TCGA pan-cancer cohorts, UBE2O RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated UBE2O data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher UBE2O RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UBE2O expression acts as an unfavorable survival marker, although some lineages such as ESCA and BRCA show a favorable association.

KIRP, LIHC, and MESO are the cancer types where UBE2O RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.628	0.850	<.001	173	view →
LIHC	DFS	Median	All	0.449	0.633	<.001	78	view →
MESO	OS	Median	III,IV	0.274	0.488	.002	43	view →
KICH	OS	Median	All	0.700	1.000	.005	43	view →
ACC	DFS	Quartile	All	0.336	0.788	<.001	38	view →
SKCM	OS	Tertile	III,IV	0.263	0.497	<.001	36	view →
KIRC	DFS	Median	All	0.555	0.725	.001	34	view →
LUSC	DFS	Median	III,IV	0.512	0.914	.006	25	view →
COAD	DFS	Tertile	II,III,IV	0.285	0.756	.001	24	view →
ESCA	DFS	Median	All	0.927	0.454	.004	18	view →
BRCA	DFS	Median	III,IV	0.915	0.839	.014	16	view →
SCLC	OS	Quartile	All	0.528	0.149	.014	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

UBE2O–KIRP (OS)

Open the KIRP breakdown →