UBE2O

Across TCGA cell cohorts, UBE2O mutation is significantly associated with the RNA expression of many other genes, with 641 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UBE2O-associated genes across cancer lineages are GPR180, MAP3K8, and LYSMD1. Each is linked with UBE2O in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2O-to-partner and partner-to-UBE2O results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR180 grouped by UBE2O-low versus UBE2O-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2O→partner) and Y-score (partner→UBE2O) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GPR180 →	+0.506	+3.169	.001	.009	3	2
BLOOD_Leukemia	MAP3K8 →	-1.292	-3.370	.001	.003	3	2
BLOOD_Leukemia	LYSMD1 →	+0.890	+3.321	<.001	.005	3	2
BLOOD_Leukemia	ZNF232 →	+1.074	+3.321	.004	.005	3	2
BLOOD_Leukemia	TBPL2 →	+0.061	+2.629	<.001	.002	3	2
BLOOD_Leukemia	KPNA7 →	+0.208	+2.807	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 641 associations by consensus.

GPR180 by UBE2O expression — LARGE_INTESTINE

Explore this box plot interactively →