UBE2M

Across TCGA patient cohorts, UBE2M mutation is significantly associated with the RNA expression of many other genes, with 145 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2M-associated genes across cancer lineages are RNU6-128P, RN7SL754P, and RNU6-777P. Each is linked with UBE2M in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2M-to-partner and partner-to-UBE2M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-128P grouped by UBE2M-low versus UBE2M-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2M→partner) and Y-score (partner→UBE2M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-128P →	+0.360	+4.578	<.001	.008	3	2
CESC	RN7SL754P →	+0.170	+5.345	<.001	.001	3	2
CESC	RNU6-777P →	+0.352	+4.539	<.001	.008	3	2
UCEC	RNU6-23P →	+0.537	+2.967	<.001	.002	3	2
UCEC	MTCO3P41 →	+0.173	+3.488	.005	<.001	3	2
LUSC	PGBD4P5 →	+0.103	+4.706	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 145 associations by consensus.

RNU6-128P by UBE2M expression — HNSC

Explore this box plot interactively →