UBE2M

Across TCGA cell cohorts, UBE2M mutation is significantly associated with the mutation status of many other genes, with 3,155 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBE2M-associated genes across cancer lineages are TOX4, PITX1, and FGFR1. Each is linked with UBE2M in more than 2 cancer types. Because this analysis shows association rather than direction, both UBE2M-to-partner and partner-to-UBE2M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOX4 grouped by UBE2M-low versus UBE2M-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2M→partner) and Y-score (partner→UBE2M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TOX4 →	+3.159	+4.632	<.001	<.001	1	3
BLOOD_Leukemia	PITX1 →	+4.560	+4.309	.007	.007	1	3
LARGE_INTESTINE	FGFR1 →	+2.422	+4.050	.004	.004	1	3
BLOOD_Leukemia	MAP7D1 →	+3.145	+3.932	.004	.004	1	3
LARGE_INTESTINE	STK11 →	+4.329	+4.329	.001	.001	1	3
BLOOD_Leukemia	IKZF4 →	+4.560	+4.309	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,155 associations by consensus.

TOX4 by UBE2M expression — LARGE_INTESTINE

Explore this box plot interactively →