UBE2I

Across TCGA patient cohorts, UBE2I mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2I-associated genes across cancer lineages are Heregulin, INPP4B, and JNK_pT183_Y185. Each is linked with UBE2I in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2I-to-partner and partner-to-UBE2I results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by UBE2I-low versus UBE2I-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2I→partner) and Y-score (partner→UBE2I) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.184	-2.321	.001	.034	3	1
UCEC	INPP4B →	-0.360	-3.169	.021	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.262	-3.169	.001	.018	3	1
UCEC	Ku80 →	+0.268	+2.472	.019	.011	3	1
UCEC	LKB1 →	-0.111	-3.000	.030	.036	3	1
UCEC	NF2 →	+0.312	+2.999	.002	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Heregulin by UBE2I expression — UCEC

Explore this box plot interactively →