UBE2I

Across TCGA pan-cancer cohorts, UBE2I RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of UBE2I’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UBE2I RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBE2I is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where UBE2I tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBE2I RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.752	<.001	12	view →
KIRC	Female	All	+0.727	<.001	12	view →
KIRP	All	IV	+1.592	<.001	11	view →
COAD	Male	IV	+1.048	<.001	11	view →
THCA	Male	III,IV	+0.531	<.001	10	view →
LIHC	Female	III,IV	+1.426	<.001	9	view →
LUAD	Male	All	+0.330	<.001	9	view →
STAD	All	II,III,IV	+0.697	<.001	8	view →
LUSC	All	All	+0.503	<.001	6	view →
BRCA	All	II,III,IV	+0.366	<.001	6	view →
CHOL	Male	All	+2.598	<.001	5	view →
UCEC	All	All	−0.433	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

UBE2I–HNSC

Open the HNSC breakdown →