UBE2I

Across TCGA cell cohorts, UBE2I RNA expression is significantly associated with the go_rna of many other GO terms, with 4,334 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible UBE2I-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cell PML body, Regulation of chromatin organization, and DNA-templated DNA replication maintenance of fidelity. Each is linked with UBE2I in more than 13 cancer types. Because this analysis shows association rather than direction, both UBE2I-to-partner and partner-to-UBE2I results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cell PML body grouped by UBE2I-low versus UBE2I-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2I→partner) and Y-score (partner→UBE2I) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Symbiont-mediated disruption of host cell PML body →	+0.103	+0.568	<.001	<.001	3	14
LUNG_SCLC	Regulation of chromatin organization →	+0.105	+0.743	<.001	<.001	3	14
BONE	DNA-templated DNA replication maintenance of fidelity →	+0.166	+0.821	<.001	<.001	3	13
BONE	DNA replication-dependent chromatin assembly →	+0.227	+0.828	<.001	<.001	3	13
BONE	Regulation of cell cycle checkpoint →	+0.120	+0.631	.006	.003	3	13
BREAST	Regulation of mitotic cytokinetic process →	+0.150	+0.838	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,334 associations by consensus.

Symbiont-mediated disruption of host cell PML body by UBE2I expression — LUNG_SCLC

Explore this box plot interactively →