UBB

Across TCGA patient cohorts, UBB mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBB-associated genes across cancer lineages are FoxM1, JNK_pT183_Y185, and Rictor_pT1135. Each is linked with UBB in more than 1 cancer types. Because this analysis shows association rather than direction, both UBB-to-partner and partner-to-UBB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by UBB-low versus UBB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBB→partner) and Y-score (partner→UBB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.342	+2.817	.011	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.262	-3.169	.002	.019	3	1
UCEC	Rictor_pT1135 →	-0.125	-3.321	.020	.010	3	1
UCEC	Bax →	+0.411	+3.321	.001	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.950	+3.019	.002	.019	3	1
UCEC	Caspase-8 →	-0.338	-3.143	.010	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

FoxM1 by UBB expression — UCEC

Explore this box plot interactively →