UBB

Across TCGA pan-cancer cohorts, UBB RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of UBB’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where UBB RNA is repressed in tumor relative to normal tissue. In most cancer types UBB is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and KICH are the cancer types where UBB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.712	<.001	9	view →
LUAD	Female	III,IV	−0.660	<.001	9	view →
KICH	Female	II,III,IV	−1.320	<.001	8	view →
LUSC	All	All	−0.563	<.001	7	view →
KIRC	Male	All	−0.264	<.001	4	view →
BRCA	Female	All	+0.181	.006	4	view →
READ	Female	All	−0.788	<.001	3	view →
BLCA	Female	IV	−0.946	.047	1	view →
LIHC	Male	All	+0.257	.008	1	view →
KIRP	All	All	−0.255	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

UBB–THCA

Open the THCA breakdown →