UBB

Across TCGA pan-cancer cohorts, UBB RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated UBB data layer compared with 2 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher UBB RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated UBB expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

KIRC, UVM, and LUSC are the cancer types where UBB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.727	0.527	<.001	79	view →
UVM	OS	Quartile	All	0.344	0.950	<.001	66	view →
LUSC	OS	Quartile	II,III,IV	0.239	0.595	<.001	59	view →
KICH	DFS	Tertile	III,IV	0.327	1.000	.002	49	view →
STAD	OS	Tertile	II,III,IV	0.570	0.831	.004	45	view →
LGG	OS	Median	All	0.742	0.872	<.001	37	view →
MESO	OS	Tertile	All	0.372	0.165	.006	34	view →
OV	OS	Quartile	All	0.748	0.614	.002	32	view →
ESCA	OS	Median	III,IV	0.440	0.717	.005	29	view →
CHOL	OS	Median	All	0.390	0.839	.010	26	view →
ACC	DFS	Tertile	All	0.228	0.704	.002	22	view →
LIHC	DFS	Quartile	All	0.405	0.207	.001	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

UBB–KIRC (DFS)

Open the KIRC breakdown →