UBASH3B

Across TCGA patient cohorts, UBASH3B mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBASH3B-associated genes across cancer lineages are ATM, GSK3-a-b, and Cyclin-B1. Each is linked with UBASH3B in more than 2 cancer types. Because this analysis shows association rather than direction, both UBASH3B-to-partner and partner-to-UBASH3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by UBASH3B-low versus UBASH3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBASH3B→partner) and Y-score (partner→UBASH3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.623	-1.874	<.001	.002	3	3
SKCM	GSK3-a-b →	+0.213	+3.169	.011	.019	3	2
UCEC	Cyclin-B1 →	+0.658	+3.807	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.489	+1.720	.013	.025	3	2
UCEC	eIF4E →	+0.196	+2.201	.005	<.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.095	-1.492	.023	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ATM by UBASH3B expression — UCEC

Explore this box plot interactively →