UBASH3B

Across TCGA pan-cancer cohorts, UBASH3B RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated UBASH3B data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher UBASH3B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UBASH3B expression acts as an unfavorable survival marker, although some lineages such as SKCM and READ show a favorable association.

LGG, PAAD, and LUSC are the cancer types where UBASH3B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.743	0.878	<.001	49	view →
PAAD	DFS	Median	All	0.396	0.570	.001	46	view →
LUSC	DFS	Median	III,IV	0.301	0.961	<.001	45	view →
SKCM	OS	Quartile	II,III,IV	0.925	0.808	.001	22	view →
LIHC	OS	Median	III,IV	0.455	0.756	.002	14	view →
BLCA	OS	Quartile	All	0.382	0.754	.007	12	view →
KIRC	DFS	Median	IV	0.241	0.430	.014	12	view →
STAD	DFS	Quartile	III,IV	0.461	0.798	.016	10	view →
READ	DFS	Quartile	II,III,IV	0.877	0.546	.012	8	view →
PCPG	DFS	Median	All	0.654	0.967	.003	6	view →
SCLC	DFS	Tertile	IV	0.119	0.507	.029	6	view →
ACC	OS	Median	IV	0.522	0.813	.026	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

UBASH3B–LGG (OS)

Open the LGG breakdown →