UBASH3B

Across TCGA pan-cancer cohorts, UBASH3B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of UBASH3B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UBASH3B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBASH3B is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

HNSC, LUAD, and STAD are the cancer types where UBASH3B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBASH3B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.117	<.001	12	view →
LUAD	Female	III,IV	−1.501	<.001	9	view →
STAD	Male	II,III,IV	+1.322	<.001	8	view →
BLCA	All	III,IV	+1.316	.003	8	view →
LUSC	Female	II,III,IV	−1.955	<.001	6	view →
KIRP	All	All	+0.822	.001	6	view →
UCEC	All	All	+0.777	.007	6	view →
CHOL	All	All	+2.936	<.001	3	view →
KICH	All	All	−0.625	.037	2	view →
LIHC	All	II,III,IV	+0.434	.026	2	view →
KIRC	All	All	+0.375	.007	2	view →
THCA	All	All	−0.277	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

UBASH3B–HNSC

Open the HNSC breakdown →