U2SURP

Across TCGA patient cohorts, U2SURP mutation is significantly associated with the RNA expression of many other genes, with 4,143 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible U2SURP-associated genes across cancer lineages are METTL17, PATL1, and GPHN. Each is linked with U2SURP in more than 2 cancer types. Because this analysis shows association rather than direction, both U2SURP-to-partner and partner-to-U2SURP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, METTL17 grouped by U2SURP-low versus U2SURP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (U2SURP→partner) and Y-score (partner→U2SURP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	METTL17 →	+0.240	+1.494	.009	.001	3	3
UCEC	PATL1 →	+0.450	+2.747	<.001	<.001	3	3
UCEC	GPHN →	+0.442	+2.534	<.001	<.001	3	3
UCEC	SIRT6 →	+0.388	+2.332	<.001	<.001	3	3
UCEC	PUM3 →	+0.325	+1.494	.005	.001	3	3
UCEC	DIS3 →	+0.390	+1.885	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,143 associations by consensus.

METTL17 by U2SURP expression — UCEC

Explore this box plot interactively →