U2SURP

Across TCGA pan-cancer cohorts, U2SURP RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of U2SURP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where U2SURP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types U2SURP is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, LIHC, and BLCA are the cancer types where U2SURP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in U2SURP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.353	<.001	12	view →
LIHC	Female	II,III,IV	+1.169	<.001	9	view →
BLCA	All	All	+0.745	<.001	9	view →
KIRC	All	All	+0.341	<.001	9	view →
STAD	All	II,III,IV	+0.890	<.001	8	view →
LUSC	Male	All	+1.085	<.001	7	view →
LUAD	Male	All	+0.700	<.001	7	view →
CHOL	Male	All	+2.034	<.001	5	view →
KICH	Female	All	−1.031	<.001	4	view →
COAD	Male	All	+0.622	<.001	4	view →
KIRP	All	IV	+0.779	.036	3	view →
THCA	All	All	−0.290	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

U2SURP–HNSC

Open the HNSC breakdown →