U2SURP

Across TCGA pan-cancer cohorts, U2SURP RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated U2SURP data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher U2SURP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated U2SURP expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

MESO, KICH, and UCS are the cancer types where U2SURP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.278	0.472	.003	103	view →
KICH	DFS	Median	II,III,IV	0.588	0.917	.008	66	view →
UCS	OS	Quartile	III,IV	0.630	0.111	<.001	62	view →
LIHC	OS	Median	All	0.601	0.772	<.001	61	view →
ACC	DFS	Median	All	0.398	0.734	<.001	44	view →
PAAD	OS	Quartile	All	0.472	0.815	<.001	43	view →
KIRC	DFS	Quartile	II,III,IV	0.295	0.633	<.001	40	view →
UCEC	DFS	Median	All	0.553	0.734	<.001	32	view →
LGG	OS	Median	All	0.346	0.564	<.001	26	view →
LUAD	DFS	Tertile	All	0.755	0.857	.005	26	view →
READ	OS	Median	III,IV	0.842	0.298	.005	15	view →
GBM	DFS	Quartile	All	0.546	0.247	.001	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

U2SURP–MESO (OS)

Open the MESO breakdown →