U2SURP

Across TCGA patient cohorts, U2SURP mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible U2SURP-associated genes across cancer lineages are PCNA, TFRC, and ATM. Each is linked with U2SURP in more than 2 cancer types. Because this analysis shows association rather than direction, both U2SURP-to-partner and partner-to-U2SURP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by U2SURP-low versus U2SURP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (U2SURP→partner) and Y-score (partner→U2SURP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.206	+2.247	.002	.001	3	3
UCEC	TFRC →	+0.473	+2.222	.004	.009	3	3
UCEC	ATM →	-0.529	-2.986	<.001	<.001	3	3
STAD	c-Kit →	-0.387	-3.000	.018	.036	3	2
UCEC	FoxM1 →	+0.161	+1.643	.045	.003	3	2
UCEC	ACC1 →	+0.222	+2.013	.049	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

PCNA by U2SURP expression — UCEC

Explore this box plot interactively →