U2SURP

Across TCGA cell cohorts, U2SURP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,821 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible U2SURP-associated GO terms across cancer lineages are DNA-templated DNA replication, Sister chromatid cohesion, and Epigenetic regulation of gene expression. Each is linked with U2SURP in more than 18 cancer types. Because this analysis shows association rather than direction, both U2SURP-to-partner and partner-to-U2SURP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by U2SURP-low versus U2SURP-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (U2SURP→partner) and Y-score (partner→U2SURP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.110	+0.975	<.001	<.001	3	19
SOFT_TISSUE	Sister chromatid cohesion →	+0.134	+1.211	<.001	<.001	3	19
SOFT_TISSUE	Epigenetic regulation of gene expression →	+0.072	+1.135	<.001	<.001	3	19
SOFT_TISSUE	Heterochromatin formation →	+0.076	+0.911	<.001	<.001	3	19
OESOPHAGUS	DNA replication →	+0.096	+0.660	<.001	<.001	3	18
OESOPHAGUS	Double-strand break repair →	+0.074	+0.700	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,821 associations by consensus.

DNA-templated DNA replication by U2SURP expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →